#  Gaudet Lab News 

 



 



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##  191 results 

  [### SpecificityStudio preprint on bioRxiv!

 ](/news/2026/06/specificitystudio-preprint-biorxiv) June 15, 2026 

 A key result is that sequence models that learn from the surrounding sequence context - especially protein language models - systematically bias against variants that alter specificity. Read more on bioRxiv. 

 

 

   ![Cartoon representing how results from a mutational library of DraNramp are predicted by context-free and context-aware sequence models](/sites/g/files/omnuum7206/files/styles/hwp_16_9__480x270/public/2026-06/Fig%20Gaudet%20Lab%20Website.png?h=a172e91c&itok=mjPhoWFc) 

 



 

 

   [### New preprint on determinants of Nramp transport and selectivity

 ](/news/2026/04/new-preprint-determinants-nramp-transport-and-selectivity) April 01, 2026 

 from Sam Berry, with Camille Freedman, based on high-throughput functional analysis of ~37,000 variants. Read it here. 

 

 

   ![Model on the left, and identified specificity-driving residues mapped on the DraNramp structure on the right.](/sites/g/files/omnuum7206/files/styles/hwp_16_9__480x270/public/2026-04/Figure%206%20pieces.png?h=acbdc003&itok=EM3zyVvJ) 

 



 

 

   [### New preprint - clade B Nramps do not cotransport protons

 ](/news/2026/01/new-preprint-clade-b-nramps-do-not-cotransport-protons) January 30, 2026 

 Posted on bioRxiv - suggests that transition metal selectivity evolved before proton co-transport in canonical Nramp transporters. 

 

 

   ![comparison of Mn2+ binding positions in different Nramps](/sites/g/files/omnuum7206/files/styles/hwp_16_9__480x270/public/2026-02/Bfra%20comparison%20Mn%20position.png?itok=ONVvyLkm) 

 



 

 

   [### Sanket awarded Harvard Brain Initiative Postdoc Pioneer Fellowship

 ](/news/2026/01/sanket-awarded-harvard-brain-initiative-postdoc-pioneer-fellowship) January 28, 2026 

 Sanket is using molecular dynamics to investigate insect gustatory receptors. Read more about it in the MCB News here. 

 

 

   ![Sanket headshot](/sites/g/files/omnuum7206/files/styles/hwp_16_9__480x270/public/2026-02/Sanket%20Walujkar%20HBI%20Fellowship%2020260128.jpg?h=1f0d91bf&itok=LOkjINyk) 

 



 

 

   [### JBC paper from a TRPV4 project started a long time ago!

 ](/news/2025/12/jbc-paper-trpv4-project-started-long-time-ago) December 29, 2025 

 ...with interesting results on the interactome of the TRPV4 intracellular N-terminal region. Read it here. 

 

 

   ![TRPV4 structure](/sites/g/files/omnuum7206/files/styles/hwp_16_9__480x270/public/2025-05/2024_TRPV4_paper_news.png?itok=8GYDXtX0) 

 



 

 

   [### Wasan wins 1st prize poster award at Zymo-sponsored BioFestival 2025!

 ](/news/2025/10/wasan-wins-1st-prize-poster-award-zymo-sponsored-biofestival-2025) October 26, 2025 

 See more about the event and award here on the MCB news. 

 

 

   ![Wasan receiving poster award](/sites/g/files/omnuum7206/files/styles/hwp_16_9__480x270/public/2026-02/20251018_151230.jpg?h=d62883b2&itok=7GpEzxc1) 

 



 

 

   [### Sam's News and Views piece on evolution of glutamate transporter

 ](https://doi.org/10.1038/s41594-025-01625-2) August 25, 2025 

 

   ![Evolution of ion coupling in glutamate transporters](/sites/g/files/omnuum7206/files/styles/hwp_scale_small/public/2025-08/Fig%20v4.png?itok=4sFF-BaH) 

 



 

 

   [### Elizabeth's paper on cell surface trafficking of clustered protocadherins

 ](https://www.pnas.org/doi/10.1073/pnas.2514178122) July 30, 2025 

 

   ![fluorescence microscopy images of clustered protocadherin-expressing cells](/sites/g/files/omnuum7206/files/styles/hwp_scale_small/public/2025-08/May_2025_FigureS2_icon.png?itok=WfWvs7rj) 

 



 

 

   [### Hoopes Prize awarded to Camille Freedman!

 ](/news/2025/05/hoopes-prize-awarded-camille-freedman) May 09, 2025 

 

   ![Camille Headshot 2025](/sites/g/files/omnuum7206/files/styles/hwp_16_9__480x270/public/2026-01/Camille%2C%20Freedman_IMG_2025_3.jpg?h=5de9d97a&itok=CjY8qRLt) 

 



 

 

   [### Welcome Nikita Kupko!

 ](https://gaudetlab.hsites.harvard.edu/people/nikita-kupko) February 26, 2025 

 Nikita is a Biophysics PhD student joining us to investigate 12TM-LuxR transcriptional regulators! 

 

 

   ![Nikita Kupko headshot](/sites/g/files/omnuum7206/files/styles/hwp_16_9__480x270/public/2025-03/Nikita%20Kupko%20headshot_1.jpg?itok=e9lTSAou) 

 



 

 

   [### New preprint from Elizabeth May!

 ](/news/new-preprint-elizabeth-may) October 09, 2024 

 on a clever surface delivery quantification strategy applied to clustered protocadherins. Read more here! 

 

 

   ![fluorescence microscopy images of clustered protocadherin-expressing cells](/sites/g/files/omnuum7206/files/styles/hwp_16_9__480x270/public/2025-05/May_2025_FigureS2_icon.png?itok=YE0JFURO) 

 



 

 

   [### Welcome Brooke DeJong!

 ](https://gaudetlab.hsites.harvard.edu/people/brooke-dejong) September 09, 2024 

 Sophomore concentrating in Chemistry at Harvard, joining the lab this fall after completing the FUEL program! 

 

 

   ![Brooke Headshot](/sites/g/files/omnuum7206/files/styles/hwp_16_9__480x270/public/gaudetlab/files/brooke_dejong_headshot_0.jpg?h=235e0528&itok=duy50Ra7) 

 



 

 

  

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