Gaudet Lab
Gaudet Lab at Harvard
Mission
The mission of the Gaudet Lab is to be a collegial, highly interactive, diverse and intellectually stimulating environment in which each lab member can develop into a successful scientist and progress to the next step in their career. Our research program centers on understanding the structure, function, and evolution of several families of membrane proteins, using state-of-the-art experimental and computational approaches to generate new data and incorporating analyses that leverage publicly available datasets.
Recent Gaudet Lab News
SpecificityStudio preprint on bioRxiv!
A key result is that sequence models that learn from the surrounding sequence context - especially protein language models - systematically bias against variants that alter specificity. Read more on bioRxiv.
New preprint on determinants of Nramp transport and selectivity
from Sam Berry, with Camille Freedman, based on high-throughput functional analysis of ~37,000 variants. Read it here.
New preprint - clade B Nramps do not cotransport protons
Posted on bioRxiv - suggests that transition metal selectivity evolved before proton co-transport in canonical Nramp transporters.
Sanket awarded Harvard Brain Initiative Postdoc Pioneer Fellowship
Sanket is using molecular dynamics to investigate insect gustatory receptors. Read more about it in the MCB News here.
JBC paper from a TRPV4 project started a long time ago!
...with interesting results on the interactome of the TRPV4 intracellular N-terminal region. Read it here.
Wasan wins 1st prize poster award at Zymo-sponsored BioFestival 2025!
See more about the event and award here on the MCB news.
Welcome Nikita Kupko!
Nikita is a Biophysics PhD student joining us to investigate 12TM-LuxR transcriptional regulators!
New preprint from Elizabeth May!
on a clever surface delivery quantification strategy applied to clustered protocadherins. Read more here!
Welcome Brooke DeJong!
Sophomore concentrating in Chemistry at Harvard, joining the lab this fall after completing the FUEL program!
Jacob's paper on LeuT-fold transporter conformational changes
Is now out in Structure. See more on the story here!
Welcome Paz Meyers!
Rising senior at Harvard, awarded a fellowship from the Generative AI Research Program!
Congratulations 2024 graduates!
Includes newly minted lab alums Elizabeth May, PhD, Heather Frank, PhD, and Jorge Guerra CPB '24 Harvard College!
Jorge wins Henderson Prize for his senior thesis!
Culmination of 3 years of research in the lab! New clues about Nramp-like proteins - read more here!
Structures of an insect fructose receptor
Out in Cell Reports! Channel opening, ligand pocket, and surprising pore-penetrating lipids! MCB website news item here!
Congratulations Dr. Frank!
Heather successfully defended her PhD thesis: "Structure of a silk moth fructose receptor: an ion channel involved in insect chemosensation". Beautifully illustrated thesis and presentation!
New preprint - computational analysis of conformations in LeuT-fold transporters
Led by Jacob Licht, with Sam Berry and Michael Gutierrez. Find it here.
New preprint - structure of an insect gustatory receptor!
in collaboration with Paul Garrity's lab - out on bioRxiv!
Congrats to Sri on his new paper!
on computational identification of fungal pheromone genes. You can read it here in Current Biology.
