SpecificityStudio preprint on bioRxiv!
A key result is that sequence models that learn from the surrounding sequence context - especially protein language models - systematically bias against variants that alter specificity. Read more on bioRxiv.
Gaudet Lab News
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New preprint on determinants of Nramp transport and selectivity
from Sam Berry, with Camille Freedman, based on high-throughput functional analysis of ~37,000 variants. Read it here.
New preprint - clade B Nramps do not cotransport protons
Posted on bioRxiv - suggests that transition metal selectivity evolved before proton co-transport in canonical Nramp transporters.
Sanket awarded Harvard Brain Initiative Postdoc Pioneer Fellowship
Sanket is using molecular dynamics to investigate insect gustatory receptors. Read more about it in the MCB News here.
JBC paper from a TRPV4 project started a long time ago!
...with interesting results on the interactome of the TRPV4 intracellular N-terminal region. Read it here.
Wasan wins 1st prize poster award at Zymo-sponsored BioFestival 2025!
See more about the event and award here on the MCB news.
Welcome Nikita Kupko!
Nikita is a Biophysics PhD student joining us to investigate 12TM-LuxR transcriptional regulators!
New preprint from Elizabeth May!
on a clever surface delivery quantification strategy applied to clustered protocadherins. Read more here!
Welcome Brooke DeJong!
Sophomore concentrating in Chemistry at Harvard, joining the lab this fall after completing the FUEL program!
